Introduction: Although inhalational anesthesia and nitrousoxide (N2O) are known to affect the\nintraocular pressure (IOP), little is known about the effect of nitrousoxide on the IOP during sevoflurane\nand remifentanil anesthesia. In the present study, we examined the effect of balanced\nanesthesia on the IOP. Materials and Methods: After obtaining informed consent, the patients undergoing\nabdominal surgery under general anesthesia were divided into two groups: N2O group (n\n= 10) and control group (n = 12). General anesthesia was maintained with remifentanil (0.05 - 0.3\n�¼g/kg/min), 33% O2 and 1.2% sevoflurane to keep ETCO2 of 35 - 40 mmHg following tracheal intubation.\nAfter baseline measurement of IOP (T0, 20 minutes after injection of anesthesia), the patients\nin the N2O group received 67% nitrousoxide, and the patients in the control group received\nair, with O2 and 1.2% sevoflurane. Then, IOP was measured at 1 hour (T1), 2 hours (T2), and 3\nhours (T3) after anesthesia induction in the supine position. Blood pressure and heart rate were\nrecorded at the same time interval. Results: There was no significant difference in the IOP at any\nperiod between the two groups. In both groups, the IOP at the T3 was significantly higher than that\nat T0. Conclusion: These results suggest that N2O does not affect the IOP in patients undergoing\nabdominal surgery under sevoflurane and remifentanil anesthesia.
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